Aspirin and other painkillers have an onset of 10-30 minutes. Peak efficiency is usually about 2-4 hours. To work, Aspirin contained in the tablet should be absorbed in the blood and circulated to the site of action. In the stomach, the tablet is divided into smaller pieces (it takes about 15 minutes). The larger the tablet, the slower it breaks in the stomach. Once the aspirin gets into your bloodstream, it has a half-life of about 20 minutes before it is metabolized by the liver, although there is a big variation in how long it takes.
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